Subcutaneous oxyntomodulin analogue administration reduces body weight in lean and obese rodents
نویسندگان
چکیده
منابع مشابه
Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trial.
This study investigated the effect of subcutaneously administered oxyntomodulin on body weight in healthy overweight and obese volunteers. Participants self-administered saline or oxyntomodulin subcutaneously in a randomized, double-blind, parallel-group protocol. Injections were self-administered for 4 weeks, three times daily, 30 min before each meal. The volunteers were asked to maintain the...
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Oxyntomodulin (OXM) is a circulating gut hormone released post prandially from cells of the gastrointestinal mucosa. Given intracerebroventricularly to rats, it inhibits food intake and promotes weight loss. Here we report that peripheral (ip) administration of OXM dose-dependently inhibited both fast-induced and dark-phase food intake without delaying gastric emptying. Peripheral OXM administr...
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Glucagon-like-peptide-1 (7-36) amide (GLP-1), when infused into the third ventricle (I.V.T.), reduces short-term food intake. In the present experiments, we assessed whether I.V.T. administration of GLP-1 could influence long-term food intake and body weight of lean Long Evans rats and of fatty Zucker (fa/fa) rats. In Experiment 1, we replicated the observation that 10 microg GLP-1, given I.V.T...
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At least three theories have been advanced to account for the phenomenon of appetite regulation. Brobeck1 has suggested that eating is related to the homeostasis of body temperature; Mayer considers satiety and hunger to be under the influence of a glucostatic mechanism,2 Kennedy has presented evidence that inversely correlates appetite with body fat content.8 All these proposals invoke the cen...
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Acetic acid (AcOH), a main component of vinegar, recently was found to suppress body fat accumulation in animal studies. Hence we investigated the effects of vinegar intake on the reduction of body fat mass in obese Japanese in a double-blind trial. The subjects were randomly assigned to three groups of similar body weight, body mass index (BMI), and waist circumference. During the 12-week trea...
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ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 2010
ISSN: 0307-0565,1476-5497
DOI: 10.1038/ijo.2010.110